The Science
The Italian pharmacologist and chemist Vittorio Erspamer (1909-1999) of the University of Rome, was the first person to analyse kambo secretion in a laboratory. His career spanned more than 60 years, with two Nobel Prize nominations. He is known for his identification and pharmacological study of over sixty chemical compounds, including octopamine and serotonin.
He reported that kambo secretion contained “a fantastic chemical cocktail with potential medical applications, unequalled by any other amphibian”. The “fantastic chemical cocktail” he referred to was peptides.
Kambo secretion naturally contains a unique collection of peptides. Some of these peptides are bioactive, meaning they have the ability to bind to cell receptors in humans without difficulty and perform specific functions within the body that have a positive impact on it.
The benefits of these peptides are far-reaching. In fact, several of them have been isolated and synthesised by the pharmaceutical industry. There are currently over 70 patents lodged worldwide on these synthesised peptides.
Some of the identified peptides found in kambo secretion:
Dermorpin (Sauvagine family): A potent analgesic estimated to be 30-40 times more potent than morphine. Also affects pituitary hormone release and pulmonary ventilation.
Dermaseptin (Dermaseptin family): Exhibits potent antimicrobial activity against enveloped viruses, bacteria, yeast, fungi and protozoa.This includes filamentous fungi that cause some infections accompanying AIDS and the use of immunosuppressive agents.
Adenoregulin/Dermaseptin B2 (Dermaseptin family): Shown to be effective in killing cancer cells. For more information, click here.
Tyrptophyllins: Highly potent against the yeast Candida Albicans.
Phyllomedusin (Tachykinins family): A powerful vasodilator which stimulates gastric secretions. It is responsible for the “rushing” sensation sometimes experienced during a kambo cleanse. It also affects the intestines, bowels, tear ducts and salivary glands.
Phyllokinin (Bradykinins family): Produces a long-lasting reduction in blood pressure.
Phyllocaerulein (Caerulins family): A potent analgesic. Produces smooth muscle contractions. Reduces blood pressure. Modifies sedation, thermoregulation and satiety. Partially responsible for increase of stamina and heightened sensory perception due to its action on the pituitary gland and adrenal cortex.
Phyllolitorin, [Leu8] Phyllolitorin, Rohdei-Litorin (Bombesins family): Neuropeptide acting in the central nervous system and peripheral nervous system. These produce smooth muscle contraction and stimulate gastric acid secretion.
Deltorpin (Deltorphin family): Higher affinity and selectivity for delta-opioid binding sites than any other natural compound.
Whilst there has been extensive scientific research into the activities of the individual peptides within kambo secretion, to date there have been no scientific studies on the use of the kambo secretion in its whole, natural form. Therefore we do not make any medical claims about the benefits of a kambo cleanse.
As the popularity of kambo is growing, we soon hope to have the scientific research to back up the anecdotal evidence of the thousands of people who have used kambo worldwide.
For more information on the potential benefits of these peptides, click here.
Click here for research papers